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LIDOCAINE; PRILOCAINE (LYE do kane; PRYE lo kane) prevents pain during a procedure. It numbs the area where it is applied, which blocks your nerves from sending pain signals to your brain. It belongs to a group of medications called local anesthetics.

How should I use this medication?

Apply this medication to the affected area. Use your fingertips or cotton swabs. Wash your hands before and after use. Use it as directed on the prescription label. Do not use it more often than directed.

Talk to your care team about the use of this medication in children. While it may be prescribed for children for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply. This medication is not for regular use.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

• Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Headache, unusual weakness or fatigue, shortness of breath, nausea, vomiting, rapid heartbeat, blue skin or lips, which may be signs of methemoglobinemia
• Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

• Change in skin color
• Irritation at application site

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• G6PD deficiency
• Have higher than normal levels of methemoglobin
• Heart disease
• Kidney disease
• Large areas of burned or damaged skin
• Liver disease
• Skin conditions or disease
• An unusual or allergic reaction to lidocaine, prilocaine, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breastfeeding

What may interact with this medication?

This medicine may interact with the following medications:

• acetaminophen
• certain antibiotics like dapsone, nitrofurantoin, aminosalicylic acid, sulfasalazine
• certain medicines for seizures like phenobarbital, phenytoin, valproic acid
• chloroquine
• cyclophosphamide
• flutamide
• hydroxyurea
• ifosfamide
• metoclopramide
• nitroglycerin
• other local anesthetics like pramoxine, tetracaine
• primaquine
• quinine

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

Be careful to avoid injury while the area is numb, and you are not aware of pain.