What should I tell my care team before I take this medication?
They need to know if you have any of these conditions:
- An eating disorder, such as anorexia or bulimia
- Diabetes
- Depression
- Frequently drink alcohol
- Glaucoma
- Head injury
- Heart disease
- High blood pressure
- History of a tumor or infection of your brain or spine
- History of heart attack or stroke
- History of irregular heartbeat
- History of substance use disorder or alcohol use disorder
- Kidney disease
- Liver disease
- Low levels of sodium in the blood
- Mental health condition
- Seizures
- Suicidal thoughts, plans, or attempt by you or a family member
- Taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days
- An unusual or allergic reaction to bupropion, naltrexone, other medications, foods, dyes, or preservatives
- Breast-feeding
- Pregnant or trying to become pregnant
What may interact with this medication?
Do not take this medication with any of the following:
- Linezolid
- MAOIs, such as Marplan, Nardil, and Parnate
- Methylene blue
- Opioids, such as codeine, methadone, morphine, oxycodone
- Other medications that contain bupropion, such as Zyban or Wellbutrin
This medication may also interact with the following:
- Alcohol
- Digoxin
- Disulfiram
- Some blood thinners, such as clopidogrel, ticlopidine, warfarin
- Some medications for depression, anxiety, or other mental health conditions
- Some medications for Parkinson disease, such as amantadine or levodopa
- Steroid medications, such as prednisone or cortisone
- Theophylline
This medication may affect how other medications work, and other medications may affect the way this medication works. Talk with your care team about all the medications you take. They may suggest changes to your treatment plan to lower the risk of side effects and to make sure your medications work as intended.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medication?
Visit your care team for regular checks on your progress.
This medication may cause serious skin reactions. They can happen weeks to months after starting the medication. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips, or lymph nodes in your neck or under your arms.
This medication may affect blood sugar. Ask your care team if changes in diet or medications are needed if you have diabetes.
Patients and their families should watch out for new or worsening depression or thoughts of suicide. This includes sudden changes in mood, behaviors, or thoughts. These changes can happen at any time but are more common in the beginning of treatment or after a change in dose. Call your care team right away if you experience these thoughts or worsening depression.
Avoid alcoholic drinks while taking this medication. Drinking large amounts of alcoholic beverages, using sleeping or anxiety medications, or quickly stopping the use of these agents while taking this medication may increase your risk for a seizure.
Do not drive or use heavy machinery until you know how this medication affects you. This medication can impair your ability to perform these tasks.
Inform your care team if you wish to become pregnant or think you might be pregnant. Losing weight while pregnant is not advised and may cause harm to the unborn child. Talk to your care team for more information.
What are the most serious risks of this medication?
This medication may increase thoughts of suicide. This may be more common in children, teenagers, and young adults. The risk may increase after first starting the medication and after dose changes. Talk to your care team right away if you have changes in mood and behavior or thoughts of self-harm or suicide.