Demadex contains the active ingredient torsemide, which is a diuretic of the pyridine-sulfonylurea class. It is formulated as tablets for oral administration. Key inactive ingredients in the tablets include crospovidone, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone.

How should I use this medication?

Take this medication by mouth with water. Take it as directed on the prescription label at the same time every day. Keep taking it unless your care team tells you to stop. Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine -Hearing loss, ringing in ears -Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet -Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision -Low potassium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, constipation Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Burning or tingling sensation in hands or feet -Dizziness -Headache -Stomach pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Diabetes -Gout -High or low levels of electrolytes, like magnesium, potassium, or sodium, in your blood -Kidney disease -Liver disease -An unusual or allergic reaction to torsemide, povidone, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

This medication may interact with the following: -Alcohol -Aspirin and aspirin-like medications -Celecoxib -Certain medications for blood pressure, heart disease, irregular heartbeat -Certain medications for cholesterol, such as cholestyramine -Certain medications for diabetes -Cisplatin -Cyclosporine -Ephedra -Ginseng -Lithium -Medications for infection, such as acyclovir, adefovir, amphotericin B, bacitracin, cidofovir, foscarnet, ganciclovir, gentamicin, pentamidine, vancomycin -Medications that relax muscles for surgery -NSAIDs, medications for pain and inflammation, such as ibuprofen or naproxen -Other diuretics -Pamidronate -Probenecid -Rifampin -Steroid medications, such as prednisone or cortisone -Warfarin -Zoledronic acid

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. Check your blood pressure regularly. Ask your care team what your blood pressure should be. Also, find out when you should contact them. You may need blood work done while you are taking this medication. Do not treat yourself for coughs, colds, or pain while using this medication without asking your care team for advice. Some medications may increase your blood pressure. This medication may increase blood sugar. Ask your care team if changes in diet or medications are needed if you have diabetes. You may need to be on a special diet while you are taking this medication. Ask your care team. Also, find out how many glasses of fluids you need to drink each day. Check with your care team if you have severe diarrhea, nausea, and vomiting, or if you sweat a lot. The loss of too much body fluid may make it dangerous for you to take this medication. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effects of this medication. Avoid alcoholic drinks.