Norpace ratings & reviews

Disopyramide
Company: Pfizer
Brand: Norpace
+1 more
Norpace, Norpace CR
Drug class: Cardiovascular System
+3 more
Cardiovascular System, Cardiac Therapy, Anti-arrhythmics, Anti-arrhythmics, Class I-A
Overall rating
2.9
full star full star half star empty star empty star
Ranked #7
Physician ratings
  • Efficacy: effective for its intended use
  • Safety: safe to use in humans
  • Tolerability: low drug side effects
  • Accessibility: insurance/payer coverage, cost, affordability,formulary coverage, availability in your hospital or practice setting
  • Adherence: patient compliance with treatment
Efficacy
2.8/5
Safety
2.9/5
Tolerability
3.0/5
Accessibility
3.1/5
Adherence
2.9/5

Sermo AI Overview

  • Norpace is generally viewed negatively by healthcare professionals, who rate its effectiveness for treating ventricular tachycardia at around 2.0 out of 5. Concerns about its overall safety are also significant, with average ratings around 2.8.
  • Many cardiologists point out that there are more effective alternatives than Norpace for managing ventricular tachycardia, leading to suggestions that it may not be the optimal treatment option.
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Based on insights from Sermo’s triple verified physicians

Description

Norpace contains the active ingredient disopyramide phosphate, which is an antiarrhythmic drug in capsule form available in 100 mg or 150 mg strengths. It is intended for oral administration and contains the base form of disopyramide as the phosphate salt. Key inactive ingredients in the capsules include lactose monohydrate, magnesium stearate, and sodium starch glycolate.

Source: This information is sourced from FDA and powered by AI

Dosage & Administration

How should I use this medication?

Take this medication by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medication more often than directed. Do not stop taking this medication suddenly. This may cause serious, heart-related side effects. Your care team will tell you how much medication to take. If your care team wants you to stop the medication, the dose will be slowly lowered over time to avoid any side effects.

Talk to your care team about the use of this medication in children. While this medication may be prescribed for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Side Effects

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
  • Low blood sugar (hypoglycemia)—tremors or shaking, anxiety, sweating, cold or clammy skin, confusion, dizziness, rapid heartbeat
  • Trouble passing urine

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Bloating
  • Change in sex drive or performance
  • Constipation
  • Dry eyes
  • Dry mouth
  • Gas
  • Headache
  • Nausea
  • Stomach pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings & Precautions

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Diabetes
  • Glaucoma
  • Heart disease or previous heart attack
  • Kidney disease
  • Liver disease
  • Low blood pressure
  • Malnutrition
  • Myasthenia gravis
  • Trouble passing urine
  • An unusual or allergic reaction to disopyramide, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breastfeeding

What may interact with this medication?

Do not take this medication with any of the following:

  • Amoxapine
  • Antivirals for HIV or AIDS
  • Apomorphine
  • Arsenic trioxide
  • Certain antibiotics, such as clarithromycin, erythromycin, pentamidine
  • Certain medications for depression, such as maprotiline, tricyclic antidepressants
  • Certain medications for fungal infections, such as fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
  • Certain medications for malaria, such as chloroquine, halofantrine
  • Cisapride
  • Droperidol
  • Haloperidol
  • Hawthorn
  • Methadone
  • Other medications for irregular heartbeat, such as dronedarone
  • Phenothiazines, such as chlorpromazine, mesoridazine, thioridazine
  • Pimozide
  • Ranolazine
  • Sertindole
  • Tacrolimus
  • Vardenafil
  • Verapamil

This medication may also interact with the following:

  • Certain medications for blood pressure or heart disease, such as beta blockers
  • Certain medications for seizures, such as carbamazepine, phenytoin, phenobarbital
  • Other medications that cause heart rhythm changes, such as dofetilide, ziprasidone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Check your heart rate and blood pressure as directed. Know what your heart rate and blood pressure should be and when to contact your care team. Your care team also may schedule regular tests to check your progress.

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.

This medication may cause dry eyes and blurred vision. If you wear contact lenses, you may feel some discomfort. Lubricating eye drops may help. See your care team if the problem does not go away or is severe.

Avoid extreme heat. This medication can cause you to sweat less than normal. Your body temperature could increase to dangerous levels, which may lead to heat stroke.

This medication may affect blood sugar levels. If you have diabetes, check with your care team before you change your diet or the dose of your diabetic medication.

What are the most serious risks of this medication?

If you have had a heart attack, talk to your healthcare provider before taking this medicine. Taking this medicine after a heart attack can increase the risk of a dangerous change in heartbeat or heart rhythm that may lead to death. This medicine is usually only used to treat irregular heartbeats (arrhythmia) that are life-threatening.

Source: This information is sourced from Elsevier Inc.

Disclaimer

The reviews, ratings, comments, and opinions expressed on this platform are solely those of the individual medical professionals who posted them and do not reflect the views or positions of Sermo, Inc. Sermo does not endorse, verify, or validate the content of individual reviews. The information provided is user-generated and reflects personal clinical experiences, which may not be complete, accurate, or applicable to your specific health needs. It is not intended as medical advice.

Prescription medications affect individuals differently, and what works for one person may not work for another. Always consult your doctor, pharmacist, or other qualified healthcare provider to ensure the information displayed applies to your personal circumstances. Only a licensed healthcare provider can advise you on what is safe and effective for you.

Keep all medications out of the reach of children, never share your medicine with others, and use each medication only as prescribed. Your reliance on any information provided on this platform is at your own risk.

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