Orap ratings & reviews

Pimozide
Company: Teva
Brand: Orap
Drug class: Central and Peripheral Nervous System
+3 more
Central and Peripheral Nervous System, Psycholeptics, Antipsychotics, First Generation Antipsychotics
Overall rating
3.1
full star full star full star empty star empty star
Ranked #2
Physician ratings
  • Efficacy: effective for its intended use
  • Safety: safe to use in humans
  • Tolerability: low drug side effects
  • Accessibility: insurance/payer coverage, cost, affordability,formulary coverage, availability in your hospital or practice setting
  • Adherence: patient compliance with treatment
Efficacy
3.4/5
Safety
2.9/5
Tolerability
3.1/5
Accessibility
3.0/5
Adherence
3.1/5

Sermo AI Overview

  • Orap is the only antipsychotic approved for Tourette syndrome, addressing a significant treatment gap for this condition. However, its effectiveness may be limited by potential side effects and the risk of interactions with other medications.
  • Mixed experiences with Orap's safety and efficacy as a standalone treatment have been reported, with some physicians raising concerns about its overall safety profile in managing Tourette syndrome.
  • Was this summary helpful?
Based on insights from Sermo’s triple verified physicians

Description

Orap contains the active ingredient pimozide, an antipsychotic from the diphenyl-butylpiperidine series. It is formulated as an oral tablet available in 1 mg and 2 mg strengths. Inactive ingredients include calcium stearate, microcrystalline cellulose, lactose anhydrous, and corn starch.

Source: This information is sourced from FDA and powered by AI

Dosage & Administration

How should I use this medication?

Take this medication by mouth with a glass of water. Follow the directions on the prescription label. Do not take with grapefruit juice. Take your doses at regular intervals. Do not take your medication more often than directed. Do not stop taking except on the advice of your care team.

Talk to your care team about the use of this medication in children. While this medication may be prescribed for children as young as 12 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Side Effects

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • High fever, stiff muscles, increased sweating, fast or irregular heartbeat, and confusion, which may be signs of neuroleptic malignant syndrome
  • Infection—fever, chills, cough, or sore throat
  • Uncontrolled and repetitive body movements, muscle stiffness or spasms, tremors or shaking, loss of balance or coordination, restlessness, shuffling walk, which may be signs of extrapyramidal symptoms (EPS)

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Constipation
  • Dizziness
  • Drowsiness
  • Dry mouth

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings & Precautions

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Blockage in your bowel
  • Dementia
  • Diabetes
  • Difficulty swallowing
  • Have trouble controlling your muscles
  • Heart disease
  • History of irregular heartbeat
  • If you often drink alcohol
  • Kidney disease
  • Liver disease
  • Low blood counts, like low white cell, platelet, or red cell counts
  • Low blood pressure
  • Low magnesium level in the blood
  • Low potassium level in the blood
  • Parkinson's disease
  • Prostate disease
  • Seizures
  • Trouble passing urine
  • An unusual or allergic reaction to pimozide, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following:

  • Adagrasib
  • Certain antibiotics, such as azithromycin, clarithromycin, dirithromycin, erythromycin, telithromycin
  • Certain antivirals for HIV or hepatitis
  • Certain medications for depression, such as citalopram, escitalopram, fluoxetine, paroxetine, sertraline, fluvoxamine, nefazodone, tricyclic antidepressants
  • Certain medications for fungal infections, such as fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
  • Certain medications for irregular heart beat, such as amiodarone, dofetilide, dronedarone, encainide, flecainide, propafenone, quinidine, sotalol
  • Chlorpromazine
  • Droperidol
  • Metoclopramide
  • Other medications that cause heart rhythm changes, such as dacomitinib, degarelix, encorafenib, entrectinib, eribulin, goserelin, lapatinib
  • Thioridazine
  • Zileuton
  • Ziprasidone

This medication may also interact with the following:

  • Alcohol
  • Antihistamines for allergy, cough, and cold
  • Atropine
  • Certain medications for anxiety or sleep
  • Certain medications for bladder problems, such as oxybutynin, tolterodine
  • Certain medications for stomach problems, such as dicyclomine, hyoscyamine
  • Certain medications for travel sickness, such as scopolamine
  • Epinephrine
  • General anesthetics, such as halothane, isoflurane, methoxyflurane, propofol
  • Grapefruit juice
  • Ipratropium
  • Levodopa or other medications for Parkinson's disease
  • Medications for blood pressure
  • Medications for seizures
  • Medications that relax muscles for surgery
  • Opioid medications for pain
  • Stimulant medications for ADHD, weight loss, or staying awake

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if symptoms do not start to get better or if they get worse. Do not stop taking except on your care team's advice.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase dizziness and drowsiness. Avoid alcoholic drinks.

This medication may increase blood sugar. Ask your care team if changes in diet or medications are needed if you have diabetes.

This medication can cause problems with controlling your body temperature. It can lower the response of your body to cold temperatures. If possible, stay indoors during cold weather. If you must go outdoors, wear warm clothes. It can also lower the response of your body to heat. Do not overheat. Do not over-exercise. Stay out of the sun when possible. If you must be in the sun, wear cool clothing. Drink plenty of water. If you have trouble controlling your body temperature, call your care team right away.

Source: This information is sourced from Elsevier Inc.

Disclaimer

The reviews, ratings, comments, and opinions expressed on this platform are solely those of the individual medical professionals who posted them and do not reflect the views or positions of Sermo, Inc. Sermo does not endorse, verify, or validate the content of individual reviews. The information provided is user-generated and reflects personal clinical experiences, which may not be complete, accurate, or applicable to your specific health needs. It is not intended as medical advice.

Prescription medications affect individuals differently, and what works for one person may not work for another. Always consult your doctor, pharmacist, or other qualified healthcare provider to ensure the information displayed applies to your personal circumstances. Only a licensed healthcare provider can advise you on what is safe and effective for you.

Keep all medications out of the reach of children, never share your medicine with others, and use each medication only as prescribed. Your reliance on any information provided on this platform is at your own risk.

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