Seysara is a tetracycline class drug with the active ingredient sarecycline in the form of sarecycline hydrochloride. It comes as an oral tablet available in dosage strengths of 60 mg, 100 mg, and 150 mg. Key inactive ingredients include microcrystalline cellulose, povidone, and sodium starch glycolate. The drug is intended for oral administration.

How should I use this medication?

Take this medication by mouth with a full glass of water. Take it as directed on the prescription label at the same time every day. Do not cut, crush, or chew this medication. Swallow the tablets whole. You can take it with or without food. If it upsets your stomach, take it with food. Take all the medication unless your care team tells you to stop it early. Keep taking it even if you think you are better. Take products with aluminum, calcium, magnesium, bismuth subsalicylate, or iron in them at a different time of day than this medication. Talk to your care team if you have questions. Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 9 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets. Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from moisture. Keep the container tightly closed. Avoid exposure to extreme heat. Get rid of any unused medication after the expiration date. To get rid of medications that are no longer needed or have expired: -Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location. -If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Increased pressure around the brain—severe headache, blurry vision, change in vision, nausea, vomiting -Infection—fever, chills, cough, or sore throat -Sensitivity to light -Severe diarrhea, fever -Unusual vaginal discharge, itching, or odor Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Dizziness -Feeling faint or lightheaded -Nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Stomach or intestine problems, such as colitis -Take medications that treat or prevent blood clots -Vision problems -An unusual or allergic reaction to sarecycline, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

-Acitretin -Antacids -Bismuth subsalicylate -Certain medications that treat or prevent blood clots, such as warfarin -Digoxin -Isotretinoin -Penicillin -Sucralfate -Vitamins that contain iron

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. It may be some time before you see the benefit from this medication. Do not treat diarrhea with over the counter products. Contact your care team if you have diarrhea that lasts more than 2 days or if it is severe and watery. This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and sunscreen. Do not use sun lamps or tanning beds/booths. Tell your care team right away if you have any change in your eyesight. This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication may increase the risk of these side effects. This medication may make it more difficult to father a child. Talk to your care team if you are concerned about your fertility. Drink plenty of fluids to reduce the risk of throat irritation and damage.