Sporanox is a medication containing the active ingredient itraconazole, which is an azole antifungal agent. It is formulated as capsules containing 100 mg of itraconazole, designed for oral administration. Key inactive ingredients include black iron oxide, FD&C Blue No. 1, gelatin, and liquid glucose. The medication is intended to treat fungal infections.

How should I use this medication?

Take this medication by mouth with water. Take it as directed on the prescription label at the same time every day. Do not cut, crush, or chew this medication. Swallow whole. Take it with food. Take all of this medication unless your care team tells you to stop it early. Keep taking it even if you think you are better.

Take antacids or acid reducers (H2 blockers or PPI) at a different time of day than this medication. Take these products 2 hours before or 2 hours after this medication.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light and moisture. Keep the container tightly closed. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

• Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, take the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Hearing loss
• Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
• Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
• Pain, tingling, or numbness in the hands or feet

Side effects that usually do not require medical attention (report to your doctor or health care team if they continue or are bothersome):

• Blurry vision
• Diarrhea
• Dizziness
• Headache
• Nausea
• Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• COPD, including chronic bronchitis or emphysema
• Heart disease
• Immune system problems
• Kidney disease
• Liver disease
• An unusual or allergic reaction to itraconazole, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following:

• Alfuzosin
• Avanafil
• Certain benzodiazepines, such as alprazolam, oral midazolam, triazolam
• Certain medications for blood pressure, such as felodipine, nisoldipine
• Certain medications for cancer, such as adagrasib, irinotecan, pacritinib, venetoclax
• Certain medications for cholesterol, such as lovastatin, simvastatin, lomitapide
• Certain medications for the heart, such as disopyramide, dofetilide, dronedarone, eplerenone, ivabradine, mavacamten, quinidine, ranolazine
• Certain medication for mental health conditions, such as aripiprazole, lurasidone, pimozide, thioridazine
• Certain medications for migraine, such as eletriptan, ubrogepant
• Cisapride
• Conivaptan
• Eliglustat
• Ergot alkaloids, such as dihydroergotamine, ergotamine, methylergonovine
• Finerenone
• Flibanserin
• Isavuconazonium
• Lonafarnib
• Loperamide
• Methadone
• Naloxegol
• Red yeast rice
• Silodosin
• Ticagrelor
• Tolvaptan
• Voclosporin

This medication may also interact with the following:

• Colchicine
• Fesoterodine
• Other medications that cause heart rhythm changes
• Solifenacin

This medication may affect how other medications work, and other medications may affect the way this medication works. Talk with your care team about all of the medications you take. They may suggest changes to your treatment plan to lower the risk of side effects and to make sure your medications work as intended.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

You may need blood work while taking this medication.

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells.

What are the most serious risks of this medication?

Itraconazole should not be given with certain other medications due to the risk for serious and sometimes life-threatening side effects.

This medicine may cause heart failure. If you already have reduced heart function, you may be at greater risk for heart failure.

This medicine may cause new or worse heart failure. Do not take this medicine if you have severe heart failure. Talk to your healthcare provider about taking this medicine if you have symptoms of heart failure like shortness of breath or swelling.