Zegerid is a medication containing the active ingredients omeprazole, a proton-pump inhibitor, and sodium bicarbonate, an antacid. It is available in immediate-release capsule form with dosage strengths of 20 mg/1,100 mg and 40 mg/1,100 mg, intended for oral administration. Key inactive ingredients include croscarmellose sodium, sodium stearyl fumarate, gelatin, and titanium dioxide. The combination aims to inhibit gastric acid secretion and protect omeprazole in the stomach.

How should I use this medication?

Take this medication by mouth. Follow the directions on the prescription label. Empty the contents of 1 packet into a container of water. The package your medication comes in will tell you how much water to use. Stir well and drink immediately. If any medication remains after drinking, add more water, stir, and drink at once. Take this medication on an empty stomach, at least 1 hour before a meal. Take your medication at regular intervals. Do not take your medication more often than directed. Do not stop taking except on your care team's advice. A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time. Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -High bicarbonate level—confusion, tremors or shaking, feeling faint or lightheaded, nausea, vomiting, muscle spasms, numbness of the face, feet, or hands -Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet -Low magnesium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, tremors -Low vitamin B12 level—pain, tingling, or numbness in the hands or feet, muscle weakness, dizziness, confusion, trouble concentrating -Rash on the cheeks or arms that gets worse in the sun -Redness, blistering, peeling, or loosening of the skin, including inside the mouth -Severe diarrhea, fever Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Gas -Headache -Nausea -Stomach pain -Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Bartter's syndrome -Diet low in salt -Heart failure -History of low levels of calcium, magnesium, or potassium in the blood -Kidney disease -Lupus -Problems with acid-base balance in your body -An unusual reaction to omeprazole, sodium bicarbonate, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following: -Atazanavir -Clopidogrel -Nelfinavir -Rilpivirine This medication may also interact with the following: -Antifungals, such as itraconazole, ketoconazole, and voriconazole -Certain antivirals for HIV or hepatitis -Certain medications that treat or prevent blood clots, such as warfarin -Cilostazol -Citalopram -Cyclosporine -Dasatinib -Digoxin -Disfulfiram -Diuretics -Erlotinib -Iron supplements -Medications for anxiety, panic, and sleep, such as diazepam -Medications for seizures, such as carbamazepine, phenobarbital, phenytoin -Methotrexate -Mycophenolate mofetil -Nilotinib -Rifampin -St. John's Wort -Tacrolimus -Vitamin B12

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. You may need blood work done while taking this medication. This medication may cause a decrease in vitamin B12. You should make sure that you get enough vitamin B12 while you are taking this medication. Discuss the foods you eat and the vitamins you take with your care team.