CINVANTI ratings & reviews

Aprepitant
Company: Heron TX
Brand: CINVANTI
+1 more
CINVANTI, Emend
Drug class: Alimentary Tract and Metabolism
+2 more
Alimentary Tract and Metabolism, Antiemetics and Antinauseants, Substance P/Neurokinin 1 (NK1) Antagonist Antiemetics
Overall rating
3.4
full star full star full star empty star empty star
Ranked #3
Physician ratings
  • Efficacy: effective for its intended use
  • Safety: safe to use in humans
  • Tolerability: low drug side effects
  • Accessibility: insurance/payer coverage, cost, affordability,formulary coverage, availability in your hospital or practice setting
  • Adherence: patient compliance with treatment
Efficacy
3.3/5
Safety
3.4/5
Tolerability
3.6/5
Accessibility
3.0/5
Adherence
3.2/5

Sermo AI Overview

  • CINVANTI is generally well-regarded among physicians for preventing chemotherapy-induced nausea and vomiting, attaining an average efficacy rating of 4 out of 5. This highlights its overall positive reception in clinical use.
  • While CINVANTI shows strong efficacy, some physicians have raised safety concerns, leading to variable experiences among patients and differing ratings in specific specialties. This suggests careful consideration is needed when prescribing.
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Based on insights from Sermo’s triple verified physicians

Description

CINVANTI is an injectable emulsion containing the active ingredient aprepitant, which acts as a neurokinin 1 (NK) receptor antagonist. It is provided in a sterile, single-dose vial for intravenous use, with each vial containing 130 mg of aprepitant in 18 mL of emulsion. Key inactive ingredients include egg lecithin, dehydrated alcohol, sodium oleate, soybean oil, sucrose, and water for injection.

Source: This information is sourced from FDA and powered by AI

Dosage & Administration

How should I use this medication?

This medication is for injection or infusion into a vein. It is given in a hospital or clinic setting.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply.

Where should I keep my medication?

This medication is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Side Effects

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Diarrhea
  • Headache
  • Pain, tingling, or numbness in the hands or feet
  • Unusual weakness or fatigue
  • Upset stomach

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings & Precautions

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Liver disease
  • An unusual or allergic reaction to aprepitant, fosaprepitant, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following:

  • Cisapride
  • Flibanserin
  • Lomitapide
  • Pimozide

This medication may also interact with the following:

  • Diltiazem
  • Estrogen and progestin hormones
  • Medications for fungal infections, such as ketoconazole or itraconazole
  • Medications for HIV
  • Medications for seizures or to control epilepsy, such as carbamazepine or phenytoin
  • Medications used for sleep or anxiety disorders, such as alprazolam, diazepam, midazolam
  • Nefazodone
  • Paroxetine
  • Ranolazine
  • Rifampin
  • Some chemotherapy medications, such as etoposide, ifosfamide, vinblastine, vincristine
  • Some antibiotics, such as clarithromycin, erythromycin, troleandomycin
  • Steroid medications, such as dexamethasone or methylprednisolone
  • Tolbutamide
  • Warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress.

Do not take this medication if you already have nausea and vomiting. Ask your care team what to do if you already have nausea.

Estrogen and progestin hormones may not work as well while you are taking this medication. Contraception is recommended while taking this medication and for 1 month after the last dose. Talk to your care team about contraceptive options. They can help you find the option that works for you.

This medication should not be used continuously for a long time.

This medication may change your liver function blood test results.

Source: This information is sourced from Elsevier Inc.

Disclaimer

The reviews, ratings, comments, and opinions expressed on this platform are solely those of the individual medical professionals who posted them and do not reflect the views or positions of Sermo, Inc. Sermo does not endorse, verify, or validate the content of individual reviews. The information provided is user-generated and reflects personal clinical experiences, which may not be complete, accurate, or applicable to your specific health needs. It is not intended as medical advice.

Prescription medications affect individuals differently, and what works for one person may not work for another. Always consult your doctor, pharmacist, or other qualified healthcare provider to ensure the information displayed applies to your personal circumstances. Only a licensed healthcare provider can advise you on what is safe and effective for you.

Keep all medications out of the reach of children, never share your medicine with others, and use each medication only as prescribed. Your reliance on any information provided on this platform is at your own risk.

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