EYLEA is a brand name for aflibercept, a recombinant fusion protein in the form of a dimeric glycoprotein. It is formulated as an iso-osmotic solution for intravitreal injection in both a pre-filled glass syringe and a glass vial. The solution contains 2 mg of aflibercept and has key inactive ingredients such as polysorbate 20, sodium chloride, and sucrose. It is designed for intravitreal administration without antimicrobial preservatives.

How should I use this medication?

This medication is injected into the eye by a care team that specializes in this treatment.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Eye pain, redness, irritation, or discharge with blurry or decreased vision
• Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
• Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
• Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Blurry vision
• Eye pain
• Increased tears
• Small spots floating in vision

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Eye infection
• Eye inflammation
• Glaucoma
• Recent eye surgery
• An unusual or allergic reaction to aflibercept, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

What may interact with this medication?

Interactions are not expected. Do not use any other eye products without talking to your care team.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication.

Tell your care team right away if you have any change in your eyesight. This medication may cause temporary blurred vision. Do not drive or use machinery until your vision has returned to normal.

Talk to your care team if you may be pregnant. Serious birth defects can occur if you take this medication during pregnancy and for 3 months after the last dose. Contraception is recommended while taking this medication and for 3 months after the last dose. Your care team can help you find the option that works for you.

Talk to your care team before breastfeeding. Changes to your treatment plan may be needed.