Lovenox contains enoxaparin sodium, a form of low molecular weight heparin, in a sterile aqueous solution. It is formulated in both prefilled single-dose syringes and multiple-dose vials for injection use. The syringes contain either 10 mg or 15 mg of enoxaparin sodium per 0.1 mL. Key inactive ingredients include water for injection and benzyl alcohol.

How should I use this medication?

This medication is injected under the skin. You will be taught how to prepare and give it. For your therapy to work as well as possible, take each dose exactly as prescribed on the prescription label. Do not skip doses. Skipping or stopping this medication can increase your risk of a blood clot. Keep taking this medication unless your care team tells you to stop. It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your care team to get one. This medication comes with INSTRUCTIONS FOR USE. Ask your pharmacist for directions on how to use this medicine. Read the information carefully. Talk to your care team if you have questions. Talk to your care team about use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. If your injections have been specially prepared, you may need to store them in the refrigerator. Ask your pharmacist. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Pain, redness, or irritation at the injection site -Swelling of the ankles, hands, or feet

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Bleeding disorder, hemorrhage, or hemophilia -Infection of the heart or heart valves -Kidney disease -Liver disease -Previous stroke -Prosthetic heart valve -Recent surgery -Recent delivery of a baby -Stomach ulcers, other stomach or intestine problems -An unusual or allergic reaction to enoxaparin, heparin, pork or pork products, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breastfeeding

What may interact with this medication?

-Aspirin and aspirin-like medications -Certain medications that prevent or treat blood clots -Dipyridamole -NSAIDs, medications for pain and inflammation, such as ibuprofen or naproxen

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. You may need blood work done while you are taking this medication. Your condition will be monitored carefully while you are receiving this medication. It is important not to miss any appointments. This medication comes in different strengths. Make sure you receive the same strength of medication with each refill. Contact your care team before using this medication if you are given a different strength. If you are going to need surgery or other procedure, tell your care team that you are using this medication. Using this medication for a long time may weaken your bones and increase the risk of bone fractures. Avoid sports and activities that might cause injury while you are using this medication. Severe falls or injuries can cause unseen bleeding. Be careful when using sharp tools or knives. Consider using an electric razor. Take special care brushing or flossing your teeth. Report any injuries, bruising, or red spots on the skin to your care team. Wear a medical ID bracelet or chain. Carry a card that describes your disease and details of your medication and dosage times.

What are the most serious risks of this medication?

People who take this medication and have a spinal procedure are at risk of forming a blood clot in the space around the brain or spinal cord. This could cause paralysis (not being able to move). The risk is higher in people who have spinal problems or injuries, have had spinal surgery in the past, and for those with a tube (catheter) in their back. Taking other medications that also affect bleeding, such as NSAIDs or other blood thinners, can also increase the risk. Your care team will watch you closely. Let them know right away if you feel pain, tingling, or numbness in your legs or feet.