Methergine contains the active ingredient methylergonovine maleate, a semi-synthetic ergot alkaloid. It is formulated as a tablet intended for oral use, with each tablet containing 0.2 mg methylergonovine maleate. The key inactive ingredients include acacia, gelatin, lactose monohydrate, and microcrystalline cellulose. It is used for the prevention and control of postpartum hemorrhage.

How should I use this medication?

Take this medication by mouth with water. Take it as directed on the prescription label. Do not use it more often than directed. Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, skip it. Take your next dose at the normal time. Do not take extra or 2 doses at the same time to make up for the missed dose.

Where should I keep my medication?

Keep out of the reach of children and pets. Store at room temperature below 25 degrees C (77 degrees F). Protect from light. Keep the container tightly closed. Get rid of any unused medication after the expiration date. To get rid of medications that are no longer needed or have expired: -Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location. -If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded -Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing -Increase in blood pressure -Pain, tingling, or numbness in the hands or feet -Seizures -Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): -Change in taste -Diarrhea -Dizziness -Hearing loss, ringing in ears -Nausea -Stomach pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Circulation problems -Heart disease -High blood pressure -Infection -Kidney disease -Liver disease -An unusual or allergic reaction to methylergonovine, ergot alkaloids, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following: -Certain antibiotics, such as clarithromycin, erythromycin, or troleandomycin -Certain antivirals for HIV or hepatitis -Conivaptan -Grapefruit juice -Imatinib -Medications for fungal infections, such as itraconazole, ketoconazole, and voriconazole -Medications used to treat migraines, such as almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, or zolmitriptan -Nefazodone -Other ergot alkaloids, such as ergotamine, dihydroergotamine This medication may also interact with the following: -Certain medications for blood pressure, heart disease, irregular heartbeat -Clotrimazole -Decongestants, such as phenylephrine and pseudoephedrine -Fluconazole -Fluoxetine -Fluvoxamine -Medications used for surgery -Nitrates, such as nitroglycerin -Stimulant medications for attention disorders, weight loss, or staying awake -Zileuton

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. Follow the instructions of your care team after childbirth. Do not breast-feed while taking this medication and for 12 hours after the last dose. Talk to your care team for more information.