Migranal ratings & reviews

Dihydroergotamine
Company: Bausch
Brand: Migranal
Drug class: Central and Peripheral Nervous System
+3 more
Central and Peripheral Nervous System, Analgesics, Anti-migraine Agents, Ergot Alkaloids
Overall rating
3.3
full star full star full star empty star empty star
Ranked #17
Physician ratings
  • Efficacy: effective for its intended use
  • Safety: safe to use in humans
  • Tolerability: low drug side effects
  • Accessibility: insurance/payer coverage, cost, affordability,formulary coverage, availability in your hospital or practice setting
  • Adherence: patient compliance with treatment
Efficacy
3.6/5
Safety
3.2/5
Tolerability
3.2/5
Accessibility
3.3/5
Adherence
3.3/5

Sermo AI Overview

  • Migranal is generally considered effective for treating both migraines and cluster headaches, particularly for patients who don't respond well to triptans, as noted by some physicians rating its efficacy highly.
  • Despite its noted efficacy, Migranal faces challenges concerning safety and tolerability, with patients often finding the nasal spray delivery method unappealing and experiencing difficulties due to cost and insurance coverage.
  • Migranal is not recommended as a first-line treatment according to some guidelines, indicating it may not be the best choice for all patients, even though it continues to be used by some as a secondary option.
  • Overall, Migranal has received a mixed reception among users with concerns about its high cost and limited insurance coverage, contributing to variability in patient access and treatment options.
  • Was this summary helpful?
Based on insights from Sermo’s triple verified physicians

Description

Migranal contains dihydroergotamine mesylate in the form of a mesylate salt. It is a nasal spray intended for intranasal administration, provided as a clear, colorless to light yellow aqueous solution.

Source: This information is sourced from FDA and powered by AI

Dosage & Administration

How should I use this medication?

This medication is for use in the nose. Take it as directed on the prescription label at the same time every day. Do not use it more often than directed. Make sure that you are using your nasal spray correctly. Ask your care team if you have any questions.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply. This medication is not for regular use. It should only be used as needed.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Do not freeze. Do not refrigerate. Protect from light. Get rid of any unused medication 8 hours after priming the spray.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, take the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Side Effects

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Burning, pain, tingling, or color changes in the hands, arms, legs, or feet
  • Dry cough, shortness of breath or trouble breathing
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Increase in blood pressure
  • Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
  • Sudden or severe stomach pain, bloody diarrhea, fever, nausea, vomiting
  • Pain in the lower back or sides

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Change in taste
  • Diarrhea
  • Dizziness
  • Irritation inside the mouth or throat
  • Nausea
  • Runny or stuffy nose
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings & Precautions

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Chest pain
  • Having or recent surgery
  • Heart attack
  • Heart disease
  • High blood pressure
  • Infection
  • Kidney disease
  • Liver disease
  • An unusual or allergic reaction to dihydroergotamine, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following:

  • Adagrasib
  • Bromocriptine
  • Ceritinib
  • Certain antibiotics, such as erythromycin or clarithromycin
  • Certain antivirals for HIV or hepatitis
  • Certain medications for fungal infections, such as itraconazole, ketoconazole, posaconazole, voriconazole
  • Certain medications for migraine headache, such as almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
  • Cocaine
  • Ergot alkaloids, such as dihydroergotamine, ergonovine, ergotamine, methylergonovine
  • Idelalisib
  • Imatinib
  • Isoproterenol
  • Lonafarnib
  • Mifepristone
  • Nefazodone
  • Nitrates
  • Pseudoephedrine
  • Ribociclib
  • Tucatinib

This medication may also interact with the following:

  • Certain medications for blood pressure, heart disease, irregular heartbeat
  • Certain medications for depression, anxiety, or mental health conditions
  • Certain medications for fungal infections, such as clotrimazole or fluconazole
  • Nicotine
  • Zileuton

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause serious birth defects.

Tell your care team right away if you notice unexplained wounds on your fingers or toes while taking this medication. You should also tell your care team if you experience numbness or pain, changes in the skin color, or sensitivity to temperature in your fingers or toes.

What are the most serious risks of this medication?

This medicine can cause toxicity that results in reduced blood flow to parts of the body, including the fingers, toes and limbs. In severe toxicity, chest pain, heart attack, or stroke may occur.

Source: This information is sourced from Elsevier Inc.

Disclaimer

The reviews, ratings, comments, and opinions expressed on this platform are solely those of the individual medical professionals who posted them and do not reflect the views or positions of Sermo, Inc. Sermo does not endorse, verify, or validate the content of individual reviews. The information provided is user-generated and reflects personal clinical experiences, which may not be complete, accurate, or applicable to your specific health needs. It is not intended as medical advice.

Prescription medications affect individuals differently, and what works for one person may not work for another. Always consult your doctor, pharmacist, or other qualified healthcare provider to ensure the information displayed applies to your personal circumstances. Only a licensed healthcare provider can advise you on what is safe and effective for you.

Keep all medications out of the reach of children, never share your medicine with others, and use each medication only as prescribed. Your reliance on any information provided on this platform is at your own risk.

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