ONZETRA ratings & reviews

The brand name Onzetra contains the active ingredient sumatriptan in the form of sumatriptan succinate, which is a selective 5-hydroxy-tryptamine receptor subtype 1 (5-HT) agonist, also known as a triptan. This medication is formulated as a nasal powder administered using a breath-powered delivery device called the Xsail, with a dosage strength of 11 mg per nosepiece and a total of 22 mg per treatment episode. Key inactive components include a hypromellose capsule. Onzetra is designed for nasal administration specifically to deliver sumatriptan to treat migraines based on the triptan class and formulation.

How should I use this medication?

This medication is for use in the nose. Follow the directions on your product or prescription label. Do not use more often than directed. Make sure that you are using your nasal spray correctly. Ask your care team if you have any questions.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply. This medication is not for regular use.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Burning, pain, tingling, or color changes in the legs or feet
• Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
• Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
• Increase in blood pressure
• Raynaud's—cool, numb, or painful fingers or toes that may change color from pale, to blue, to red
• Seizures
• Serotonin syndrome—irritability, confusion, fast or irregular heartbeat, muscle stiffness, twitching muscles, sweating, high fever, seizure, chills, vomiting, diarrhea
• Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
• Sudden or severe stomach pain, nausea, vomiting, fever, or bloody diarrhea
• Vision loss

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Change in taste
• Dizziness
• General discomfort or fatigue
• Irritation inside the nose or throat
• Runny or stuffy nose

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Circulation problems in fingers and toes
• Diabetes
• Heart disease
• High blood pressure
• High cholesterol
• History of irregular heartbeat
• History of stroke
• Kidney disease
• Liver disease
• Stomach or intestine problems
• Tobacco use
• An unusual or allergic reaction to sumatriptan, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breastfeeding

What may interact with this medication?

Do not take this medication with any of the following:

• Certain medications for migraine headache, such as almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
• Ergot alkaloids, such as dihydroergotamine, ergonovine, ergotamine, methylergonovine
• MAOIs, such as Carbex, Eldepryl, Marplan, Nardil, and Parnate

This medication may also interact with the following:

• Certain medications for mental health conditions

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

Tell your care team right away if you have any change in your eyesight.

If you take migraine medications for 10 or more days a month, your migraines may get worse. Keep a diary of headache days and medication use. Contact your care team if your migraine attacks occur more frequently.