Persantine contains the active ingredient dipyridamole, which is a platelet inhibitor. The medication is available in tablet form for oral administration with dosage strengths of 25 mg, 50 mg, and 75 mg. Key inactive ingredients include corn starch, lactose monohydrate, and magnesium stearate. Persantine is designed to prevent platelet aggregation, which can lower the risk of blood clots.

How should I use this medication?

Take this medication by mouth with a full glass of water. Take it as directed on the prescription label at the same time every day. Keep taking it unless your care team tells you to stop.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

• Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Chest pain (angina)—pain, pressure, or tightness in the chest, neck, back, or arms
• Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
• Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Diarrhea
• Dizziness
• Flushing
• Headache
• Skin rash
• Upset stomach

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of the following conditions:

• An unusual or allergic reaction to dipyridamole, tartrazine dye, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following:

• Riociguat

This medication may also interact with the following:

• Adenosine
• Medications for myasthenia gravis, such as neostigmine and pyridostigmine

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Check your heart rate and blood pressure regularly while you are taking this medication. Ask your care team what your heart rate and blood pressure should be, and when you should contact them.

Notify your care team and seek emergency treatment if you develop breathing problems, changes in vision, chest pain, severe, sudden headache, pain, swelling, warmth in the leg, trouble speaking, sudden numbness or weakness of the face, arm, or leg. These can be signs that your condition has gotten worse.

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

Ask your care team before you take non-prescription pain relievers. Avoid aspirin and aspirin-containing products.

If you are going to need surgery or other procedure, tell your care team that you are taking this medication.