SILIQ ratings & reviews

Brodalumab
Company: Bausch
Brand: SILIQ
Drug class: Antineoplastic and Immunomodulating Agents
+6 more
Antineoplastic and Immunomodulating Agents, Dermatologicals, Agents that Suppress the Immune System, Nonsteroidals For Inflammatory Skin Disorders, Interleukin-17A (IL-17A) Inhibitors, Systemic Antipsoriasis Agents, Antipsoriatic Monoclonal Antibodies and Others
Overall rating
3.4
full star full star full star empty star empty star
Ranked #35
Physician ratings
  • Efficacy: effective for its intended use
  • Safety: safe to use in humans
  • Tolerability: low drug side effects
  • Accessibility: insurance/payer coverage, cost, affordability,formulary coverage, availability in your hospital or practice setting
  • Adherence: patient compliance with treatment
Efficacy
3.6/5
Safety
3.4/5
Tolerability
3.6/5
Accessibility
3.1/5
Adherence
3.5/5

Sermo AI Overview

  • Siliq is generally regarded as an effective treatment for psoriasis, particularly among dermatologists, achieving efficacy scores often around 4 out of 5. However, concerns about accessibility persist, with many physicians noting that prior treatment failures are often required for approval.
  • Significant safety concerns exist surrounding Siliq, especially due to black box warnings that highlight risks such as suicidal ideation, which has led to hesitancy among some healthcare providers.
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Based on insights from Sermo’s triple verified physicians

Description

SILIQ contains the active ingredient brodalumab in the form of a human monoclonal IgG2Îş antibody. It is designed to interact with human interleukin-17 receptor A (IL-17RA). The drug is delivered as an injection, with each prefilled syringe containing 210 mg of brodalumab in a sterile solution for subcutaneous use. Key inactive ingredients include glutamate, polysorbate 20, and proline. Brodalumab is commonly used to modify immune responses and treat conditions like psoriasis.

Source: This information is sourced from FDA and powered by AI

Dosage & Administration

How should I use this medication?

This medication is injected under the skin. It is usually given by your care team in a hospital or clinic setting. It may also be given at home.

If you get this medication at home, you will be taught how to prepare and give it. Use exactly as directed. Take it as directed on the prescription label at the same time every day. Keep taking it unless your care team tells you to stop.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or care team to get one.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If your get this medication at the hospital or clinic: It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

If you give yourself this medication at home: If you miss a dose, take it as soon as you can. Then continue your normal schedule. Do not take double or extra doses. Call your care team with questions.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store in the refrigerator. Do not freeze. Keep this medication in the original packaging until you are ready to take it. Protect from light. Do not shake. Prior to use, remove the syringe from the refrigerator and use within 30 minutes. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, ask your pharmacist or care team how to get rid of this medication safely.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Side Effects

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
  • Sudden or severe stomach pain, bloody diarrhea, fever, nausea, vomiting
  • Thoughts of suicide or self-harm, worsening mood, feelings of depression

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Diarrhea
  • Fatigue
  • Headache
  • Joint pain
  • Nausea
  • Pain, redness, or irritation at injection site
  • Sore throat

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings & Precautions

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Crohn's disease
  • Immune system problems
  • Infection
  • Recently received or are scheduled to receive a vaccine
  • Suicidal thoughts, plans, or attempt by you or a family member
  • Tuberculosis, a positive skin test for tuberculosis, or recent close contact with someone who has tuberculosis
  • An unusual or allergic reaction to brodalumab, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following:

  • Live virus vaccines

This medication may also interact with the following:

  • Cyclosporine
  • Inactivated vaccines
  • Midazolam
  • Warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

This medication may cause thoughts of suicide or depression. This includes sudden changes in mood, behaviors, or thoughts. These changes can happen at any time but are more common in the beginning of treatment or after a change in dose. Call your care team right away if you experience these thoughts or worsening depression.

You will be tested for tuberculosis (TB) before you start this medication. If your care team prescribes any medication for TB, you should start taking the TB medication before starting this medication. Make sure to finish the full course of TB medication.

This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.

This medication can decrease the response to a vaccine. If you need to get vaccinated, tell your care team if you have received this medication within the last 6 months. Extra booster doses may be needed. Talk to your care team to see if a different vaccination schedule is needed.

What are the most serious risks of this medication?

This medicine may increase thoughts about suicide. Patients of all ages and their families should watch out for new or worsening thoughts of suicide while taking this medicine. Report behaviors of concern promptly to the treating doctor.

Source: This information is sourced from Elsevier Inc.

Disclaimer

The reviews, ratings, comments, and opinions expressed on this platform are solely those of the individual medical professionals who posted them and do not reflect the views or positions of Sermo, Inc. Sermo does not endorse, verify, or validate the content of individual reviews. The information provided is user-generated and reflects personal clinical experiences, which may not be complete, accurate, or applicable to your specific health needs. It is not intended as medical advice.

Prescription medications affect individuals differently, and what works for one person may not work for another. Always consult your doctor, pharmacist, or other qualified healthcare provider to ensure the information displayed applies to your personal circumstances. Only a licensed healthcare provider can advise you on what is safe and effective for you.

Keep all medications out of the reach of children, never share your medicine with others, and use each medication only as prescribed. Your reliance on any information provided on this platform is at your own risk.

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