XIIDRA contains the active ingredient lifitegrast in an ophthalmic solution form at a concentration of 5%, designed as a lymphocyte function-associated antigen-1 (LFA-1) antagonist. The drug is formulated as a sterile, clear liquid for eye application, with each milliliter containing 50 mg of lifitegrast. Key inactive ingredients include sodium chloride, sodium phosphate dibasic anhydrous, and water for injection. It is a colorless to slightly brownish-yellow solution with a pH range of 7.0 to 8.0.

How should I use this medication?

This medication is only for use in the eye. Do not take by mouth. Follow the directions on the prescription label. Wash hands before and after use. Tilt the head back slightly and pull down the lower lid with the index finger to form a pouch. Try not to touch the tip of the dropper to your eye or into the pouch. Squeeze one drop into the pouch. Close the eye gently to spread the drops. Do not use your medication more often than directed. Finish the full course of medication prescribed by your care team even if your condition is better. Do not stop using except on the advice of your care team.

Talk to your care team about the use of this medication in children. While this medication may be prescribed for children as young as 17 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store in the original foil pouch at room temperature between 20 and 25 degrees C (68 to 77 degrees F).

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• New or worsening eye pain, redness, irritation, or discharge

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Blurry vision
• Change in taste
• Eye irritation or itching
• Headache
• Increased tears after use

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Wear contact lenses
• An unusual or allergic reaction to lifitegrast or other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

What may interact with this medication?

Interactions have not been studied.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

If you wear contact lenses, take them out before placing drops in the eye. Contact lenses may be put back in 15 minutes after putting the drops in your eyes.