What should I tell my care team before I take this medication?
They need to know if you have any of these conditions:
- Asthma
- Blood clots
- Breast cancer or family history of breast cancer
- Depression
- Diabetes
- Eating disorder (anorexia nervosa)
- Frequently drink alcohol
- Heart attack
- High blood pressure
- HIV infection or AIDS
- Kidney disease
- Liver disease
- Migraine headaches
- Osteoporosis, weak bones
- Seizures
- Stroke
- Tobacco use
- Vaginal bleeding
- An unusual or allergic reaction to medroxyprogesterone, other medications, foods, dyes, or preservatives
- Pregnant or trying to get pregnant
- Breast-feeding
What may interact with this medication?
- Antibiotics or medications for infections, especially rifampin and griseofulvin
- Antivirals for HIV or hepatitis
- Aprepitant
- Armodafinil
- Bexarotene
- Bosentan
- Medications for seizures, such as carbamazepine, felbamate, oxcarbazepine, phenytoin, phenobarbital, primidone, topiramate
- Mitotane
- Modafinil
- St. John's Wort
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medication?
Visit your care team for regular health checks while on this medication.
Using this medication does not protect you or your partner against HIV or other sexually transmitted infections (STIs).
You may need to use another form of contraception, such as a condom, when you first start taking this medication. This is called backup contraception. This helps prevent pregnancy until your medication has had time to reach its full effect. Talk to your care team. They can help you find the option that works best for you. They can also tell you how long you may need backup contraception.
This medication can decrease the amount of calcium in your bones. This weakens your bones and increases the risk of fractures. The risk increases the longer you take this medication. This effect is not reversible. Do not take this medication for more than 2 years unless you are not able to use other forms of contraception. Your care team can help you find the option that works best for you. They can also help you maintain your bone health.
This medication may change your menstrual cycle pattern. You may have irregular menstrual cycles or spotting, an increase or decrease in bleeding, or no bleeding at all. You may skip periods or your periods may stop. This is normal. If you think you may be pregnant, talk to your care team.
Talk to your care team if you plan to get pregnant within the next year. The effect of this medication may last a long time after you get your last injection.
What are the most serious risks of this medication?
Use of this birth control injection may cause you to lose calcium in your bone, which may cause weak bones (osteoporosis) later in life. The risk of weak bones increases if you use this method of birth control for more than 2 years. Your bones may not recover their strength completely. It is recommended that you do not use this type of birth control for more than 2 years.