Estrace ratings & reviews

Estradiol
Company: Allergan
Brand: Estrace
+14 more
Estrace, Imvexxy, Minivelle, EstroGel, Climara, LYLLANA, Vagifem, Vivelle-Dot, Yuvafem, Evamist, Alora, Menostar, Elestrin, Estring, Divigel
Drug class: Genito-urinary System and Sex Hormones
+2 more
Genito-urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital System, Estrogens, Excluding Hormonal Contraceptives

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Sermo AI Overview

  • Many physicians have noted the risk of endometrial hyperplasia associated with Estrace, raising safety concerns particularly for patients with a uterus, which affects its overall recommendation.
  • Accessibility and adherence to Estrace may be problematic due to recent price increases and variability in treatment consistency among patients, potentially impacting overall treatment outcomes for various conditions.
  • While Estrace may provide benefits for some patients, there's a consensus among healthcare providers regarding its inconsistent efficacy for conditions like palliative breast cancer, hypogonadism, and osteoporosis, with many suggesting alternative treatments offer better outcomes.
  • Estrace is generally well-rated for its safety and efficacy across various indications, with particular satisfaction in managing menopause symptoms and atrophic vaginitis, although concerns over safety and efficacy for conditions like osteoporosis and prostate cancer persist.
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Based on insights from Sermo’s triple verified physicians

Description

Estrace contains micronized estradiol, in the form of 17β-estradiol, as its active ingredient and is available in 0.5 mg, 1 mg, or 2 mg tablet strengths for oral administration. Key inactive ingredients include colloidal silicon dioxide, corn starch, dibasic calcium phosphate, lactose monohydrate, magnesium stearate, and sodium starch glycolate. Depending on the dosage, the tablets may also contain color additives such as FD&C blue no. 1 aluminum lake and others.

Source: This information is sourced from FDA and powered by AI

Dosage & Administration

How should I use this medication?

This medication is for use in the vagina only. Do not take by mouth. Follow the directions on the prescription label. Read package directions carefully before using. Use the special applicator supplied with the cream. Wash hands before and after use. Fill the applicator with the prescribed amount of cream. Lie on your back, part and bend your knees. Insert the applicator into the vagina and push the plunger to expel the cream into the vagina. Wash the applicator with warm soapy water and rinse well. Use exactly as directed for the complete length of time prescribed. Do not stop using except on the advice of your care team.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Talk to your care team about the use of this medication in children. This medication is not approved for use in children.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from temperatures above 40 degrees C (104 degrees C). Do not freeze. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Side Effects

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
  • Breast tissue changes, new lumps, redness, pain, or discharge from the nipple
  • Gallbladder problems—severe stomach pain, nausea, vomiting, fever
  • Increase in blood pressure
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
  • Unusual vaginal discharge, itching, or odor
  • Vaginal bleeding after menopause, pelvic pain

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Bloating
  • Breast pain or tenderness
  • Nausea
  • Vaginal irritation at application site
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings & Precautions

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Abnormal vaginal bleeding
  • Blood vessel disease or blood clots
  • Breast, cervical, endometrial, ovarian, liver, or uterine cancer
  • Dementia
  • Diabetes
  • Gallbladder disease
  • Heart disease or recent heart attack
  • High blood pressure
  • High cholesterol
  • High levels of calcium in the blood
  • Hysterectomy
  • Kidney disease
  • Liver disease
  • Migraine headaches
  • Protein C/S deficiency
  • Stroke
  • Systemic lupus erythematosus (SLE)
  • Tobacco use
  • An unusual or allergic reaction to estrogens, soy, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following:

  • Aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medication may also interact with the following:

  • Barbiturates used for inducing sleep or treating seizures
  • Carbamazepine
  • Grapefruit juice
  • Medications for fungal infections like ketoconazole and itraconazole
  • Raloxifene
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritonavir
  • Some antibiotics used to treat infections
  • St. John's Wort
  • Tamoxifen
  • Warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your care team, and follow their guidelines.

This medication can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your care team if you feel you are retaining fluid.

If you have any reason to think you are pregnant, stop taking this medication at once and contact your care team.

Smoking tobacco increases the risk of getting a blood clot or having a stroke while you are taking this medication, especially if you are older than 35 years.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist.

If you are going to have elective surgery, you may need to stop taking this medication beforehand. Consult your care team for advice prior to scheduling the surgery.

What are the most serious risks of this medication?

Do not use this medicine to prevent heart disease. Using estrogens with or without progestins may increase your chances of getting heart attacks, strokes, or blood clots.

Estrogens with progestins may increase your chances of getting breast cancer. Talk to your healthcare provider before taking this medicine if you have ever had cancer. Call your healthcare provider right away if you get new breast lumps.

Estrogens with or without progestins may increase your chance of getting dementia based on a study of women 65 years of age or older.

If you have a uterus, using estrogens alone (without progestins) may increase your chance of uterine cancer (cancer of the womb).

Source: This information is sourced from Elsevier Inc.

Disclaimer

The reviews, ratings, comments, and opinions expressed on this platform are solely those of the individual medical professionals who posted them and do not reflect the views or positions of Sermo, Inc. Sermo does not endorse, verify, or validate the content of individual reviews. The information provided is user-generated and reflects personal clinical experiences, which may not be complete, accurate, or applicable to your specific health needs. It is not intended as medical advice.

Prescription medications affect individuals differently, and what works for one person may not work for another. Always consult your doctor, pharmacist, or other qualified healthcare provider to ensure the information displayed applies to your personal circumstances. Only a licensed healthcare provider can advise you on what is safe and effective for you.

Keep all medications out of the reach of children, never share your medicine with others, and use each medication only as prescribed. Your reliance on any information provided on this platform is at your own risk.

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