The brand name of the drug is Parsabiv. The active ingredient is etelcalcetide, which is a synthetic peptide calcium-sensing receptor agonist, and is provided in the form of its hydrochloride salt. Parsabiv is formulated as an injection in a single-dose vial, available in 2.5 mg, 5 mg, and 10 mg dosage strengths for intravenous use. Key inactive ingredients include sodium chloride and succinic acid. It is designed for sterile and preservative-free administration.

How should I use this medication?

This medication is injected into a vein. It is given by your care team in a hospital or clinic setting.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

Where should I keep my medication?

This medication is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Bone pain
• Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
• Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
• Low calcium level—muscle pain or cramps, confusion, tingling, or numbness in the hands or feet
• Stomach bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

• Burning or tingling sensation in hands or feet
• Diarrhea
• Headache
• Nausea
• Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Heart disease
• History of stomach bleeding
• Low levels of calcium in your blood
• Seizures
• An unusual or allergic reaction to etelcalcetide, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

What may interact with this medication?

• Cinacalcet

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. You may need blood work done while you are taking this medication.