What should I tell my care team before I take this medication?
They need to know if you have any of these conditions:
- Diabetes
- Heart disease
- High cholesterol or triglycerides
- Infection
- Liver disease
- An unusual or allergic reaction to sirolimus, other medications, foods, dyes, or preservatives
- Pregnant or trying to get pregnant
- Breast-feeding
What may interact with this medication?
Do not take this medication with any of the following:
- Live virus vaccines
- Mifepristone
- Posaconazole
- Temsirolimus
- Voriconazole
This medication may also interact with the following:
- Bromocriptine
- Cannabidiol
- Certain antibiotics, such as clarithromycin, erythromycin, rifampin, rifabutin, telithromycin
- Certain antivirals for HIV or hepatitis
- Certain medications for blood pressure, heart disease, irregular heartbeat
- Certain medications for cholesterol, such as simvastatin
- Certain medications for fungal infections, such as clotrimazole, fluconazole, itraconazole, ketoconazole
- Certain medications for seizures, such as carbamazepine, phenobarbital, phenytoin
- Certain medications for stomach problems, such as cimetidine, cisapride, metoclopramide
- Cyclosporine
- Danazol
- Grapefruit juice
- Letermovir
- St. John's wort
- Tacrolimus
Other medications may affect the way this medication works. Talk with your care team about all of the medications you take. They may suggest changes to your treatment plan to lower the risk of side effects and to make sure your medications work as intended.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medication?
Visit your care team for regular checks on your progress. You may need blood work while you are taking this medication.
This medication can increase bad cholesterol and fats (such as LDL, triglycerides) and decrease good cholesterol (HDL) in your blood. You may need blood tests to check your cholesterol. Ask your care team what you can do to lower your risk of high cholesterol while taking this medication.
This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
This medication may increase blood sugar. The risk may be higher in patients who already have diabetes. Ask your care team what you can do to lower your risk of diabetes while taking this medication.
Talk to your care team about your risk of cancer. You may be more at risk for certain types of cancer if you take this medication.
Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause serious birth defects if taken during pregnancy and for 12 weeks after the last dose. A reliable form of contraception is recommended while taking this medication and for 12 weeks after the last dose. Talk to your care team about reliable forms of contraception.
Talk to your care team before breastfeeding. Changes to your treatment plan may be needed.
This medication may cause infertility. Talk to your care team if you are concerned about your fertility.
What are the most serious risks of this medication?
If you get this medicine for an organ transplant, it should be started in the hospital, a clinic, or in a healthcare treatment setting.
Taking this medicine can increase the risk of getting cancer.
This medicine can lower your body’s ability to fight infections. You may get more infections while taking this medicine. Any infection you get could become serious and even deadly.
This medicine should not be used for liver transplant.
This medicine should not be used for lung transplant.
This medicine should only be given by a healthcare provider who has experience in the use of transplant drugs.