Ibrance contains the active ingredient palbociclib, which is a kinase inhibitor. It comes in tablet form with dosage strengths of 125 mg, 100 mg, or 75 mg for oral administration. Key inactive ingredients include microcrystalline cellulose, magnesium stearate, succinic acid, and different coloring agents depending on the tablet strength.

How should I use this medication?

Take this medication by mouth with a glass of water. Take it as directed on the prescription label at the same time every day. Do not cut, crush, or chew this medication. Swallow the tablets whole. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop. Do not take this medication with grapefruit or grapefruit juice. Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose or vomit after taking a dose, do not take another dose on that day. Take your next dose at your regular time.

Where should I keep my medication?

Keep out of the reach of children and pets. Store between 20 and 25 degrees C (68 and 77 degrees F). Keep this medication in the original blister pack. Get rid of any unused medication after the expiration date. To get rid of medications that are no longer needed or have expired: -Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location. -If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, take the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible: -Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat -Dry cough, shortness of breath or trouble breathing -Infection—fever, chills, cough, or sore throat -Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing -Unusual bruising or bleeding Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome): -Diarrhea -Fatigue -Hair loss -Nausea -Pain, redness, or swelling with sores inside the mouth or throat -Skin rash -Unusual weakness or fatigue

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions: -Infection, such as chickenpox, cold sores, herpes -Low blood counts, such as low white cells, platelets, or red cell counts -Lung or breathing disease, such as asthma -An unusual or allergic reaction to palbociclib, other medications, foods, dyes, or preservatives -If you or your partner are pregnant or trying to get pregnant -Breastfeeding

What may interact with this medication?

-Alfentanil -Antiviral medications for HIV or AIDS -Carbamazepine -Certain medications for fungal infections, such as itraconazole, ketoconazole, posaconazole, voriconazole -Clarithromycin -Cyclosporine -Enzalutamide -Ergot alkaloids, such as dihydroergotamine, ergotamine -Everolimus -Fentanyl -Grapefruit juice -Midazolam -Nefazodone -Phenytoin -Pimozide -Quinidine -Rifampin -Sirolimus -St. John's wort -Tacrolimus -Telithromycin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication. You may need blood work done while taking this medication. This medication may make you feel generally unwell. This is not uncommon as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your care team tells you to stop. This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick. Avoid taking medications that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your care team. These medications may hide a fever. Be careful brushing or flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medication. This medication may increase your risk to bruise or bleed. Call your care team if you notice any unusual bleeding. Talk to your care team if you may be pregnant. Serious birth defects can occur if you take this medication during pregnancy and for 3 weeks after the last dose. You will need a negative pregnancy test before starting this medication. Contraception is recommended while taking this medication and for 3 weeks after the last dose. Your care team can help you find the option that works for you. If your partner can get pregnant, use a condom during sex while taking this medication and for 3 months after the last dose. Do not breastfeed while taking this medication and for 3 weeks after the last dose. This mediation may cause infertility. Talk to your care team if you are concerned about your fertility.