What should I tell my care team before I take this medication?
They need to know if you have any of these conditions:
- Liver disease
- An unusual or allergic reaction to tucatinib, other medications, foods, dyes or preservatives
- Pregnant or trying to get pregnant
- Breast-feeding
What may interact with this medication?
Do not take this medication with any of the following medications:
- Alfuzosin
- Alprazolam
- Certain medications for cholesterol, such as lovastatin, simvastatin
- Conivaptan
- Dronedarone
- Eletriptan
- Eplerenone
- Ergot alkaloids, such as dihydroergotamine or ergotamine
- Finerenone
- Flibanserin
- Isavuconazonium
- Ivabradine
- Lomitapide
- Lonafarnib
- Lurasidone
- Mavacamten
- Naloxegol
- Pacritinib
- Pimozide
- Ranolazine
- Silodosin
- Tolvaptan
- Triazolam
- Ubrogepant
- Voclosporin
This medication may also interact with the following:
- Digoxin
- Gemfibrozil
- Midazolam
- Rifampin
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medication?
This medication may make you feel generally unwell. This is not uncommon as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your care team tells you to stop.
Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause serious birth defects if taken during pregnancy or for 1 week after stopping therapy. A negative pregnancy test is required before starting this medication. A reliable form of contraception is recommended while taking this medication and for 1 week after stopping therapy. Talk to your care team about reliable forms of contraception.
Use a condom during sex and for 1 week after stopping therapy. Tell your care team right away if you think your partner might be pregnant. This medication can cause serious birth defects.
Do not breast-feed while taking this medication and for 1 week after stopping therapy.
This medication may cause infertility. Talk to your care team if you are concerned about your fertility.