TUKYSA ratings & reviews

Tucatinib
Company: Pfizer
Brand: TUKYSA
Drug class: Antineoplastic and Immunomodulating Agents
+3 more
Antineoplastic and Immunomodulating Agents, Antineoplastics, Small Molecule Antineoplastic Epidermal Growth Factor Receptor (EGFR) Inhibitors, Small Molecule Antineoplastic HER2/neu Inhibitors
Overall rating
3.6
full star full star full star half star empty star
Ranked #23
Physician ratings
  • Efficacy: effective for its intended use
  • Safety: safe to use in humans
  • Tolerability: low drug side effects
  • Accessibility: insurance/payer coverage, cost, affordability,formulary coverage, availability in your hospital or practice setting
  • Adherence: patient compliance with treatment
Efficacy
3.9/5
Safety
3.7/5
Tolerability
3.5/5
Accessibility
3.3/5
Adherence
3.4/5

Sermo AI Overview

  • TUKYSA has a mixed reception among healthcare professionals, with an overall rating of 2.8 out of 5. Accessibility and tolerability are prominent concerns, though some physicians consider it a decent option for specific cancers.
  • Efficacy perceptions of TUKYSA vary, with some specialists recognizing its potential, while others express significant concerns about its overall safety and effectiveness in the treatment of breast and colorectal cancers.
  • Was this summary helpful?
Based on insights from Sermo’s triple verified physicians

Description

Tukysa is a brand name for tucatinib, a kinase inhibitor. It is provided in the form of film-coated tablets available in 50 mg and 150 mg strengths for oral administration. Key inactive ingredients include copovidone, crospovidone, sodium chloride, and magnesium stearate. Tukysa is intended to block certain proteins involved in cancer cell growth.

Source: This information is sourced from FDA and powered by AI

Dosage & Administration

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. Do not cut, crush, or chew this medication. Swallow the tablets whole. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, skip it. Take your next dose at the normal time. Do not take extra or 2 doses at the same time to make up for the missed dose.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep this medicine in the original container until you are ready to take it. Protect from moisture. Keep the container tightly closed. Do not throw out the packet in the container. It keeps the medication dry. Get rid of any unused medication after it expires or 3 months after opening, whichever is first.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or local law enforcement to find a location.
  • If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Side Effects

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Diarrhea
  • Fatigue
  • Nausea
  • Skin rash
  • Stomach pain
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings & Precautions

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Liver disease
  • An unusual or allergic reaction to tucatinib, other medications, foods, dyes or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

What may interact with this medication?

Do not take this medication with any of the following medications:

  • Alfuzosin
  • Alprazolam
  • Certain medications for cholesterol, such as lovastatin, simvastatin
  • Conivaptan
  • Dronedarone
  • Eletriptan
  • Eplerenone
  • Ergot alkaloids, such as dihydroergotamine or ergotamine
  • Finerenone
  • Flibanserin
  • Isavuconazonium
  • Ivabradine
  • Lomitapide
  • Lonafarnib
  • Lurasidone
  • Mavacamten
  • Naloxegol
  • Pacritinib
  • Pimozide
  • Ranolazine
  • Silodosin
  • Tolvaptan
  • Triazolam
  • Ubrogepant
  • Voclosporin

This medication may also interact with the following:

  • Digoxin
  • Gemfibrozil
  • Midazolam
  • Rifampin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

This medication may make you feel generally unwell. This is not uncommon as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your care team tells you to stop.

Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause serious birth defects if taken during pregnancy or for 1 week after stopping therapy. A negative pregnancy test is required before starting this medication. A reliable form of contraception is recommended while taking this medication and for 1 week after stopping therapy. Talk to your care team about reliable forms of contraception.

Use a condom during sex and for 1 week after stopping therapy. Tell your care team right away if you think your partner might be pregnant. This medication can cause serious birth defects.

Do not breast-feed while taking this medication and for 1 week after stopping therapy.

This medication may cause infertility. Talk to your care team if you are concerned about your fertility.

Source: This information is sourced from Elsevier Inc.

Disclaimer

The reviews, ratings, comments, and opinions expressed on this platform are solely those of the individual medical professionals who posted them and do not reflect the views or positions of Sermo, Inc. Sermo does not endorse, verify, or validate the content of individual reviews. The information provided is user-generated and reflects personal clinical experiences, which may not be complete, accurate, or applicable to your specific health needs. It is not intended as medical advice.

Prescription medications affect individuals differently, and what works for one person may not work for another. Always consult your doctor, pharmacist, or other qualified healthcare provider to ensure the information displayed applies to your personal circumstances. Only a licensed healthcare provider can advise you on what is safe and effective for you.

Keep all medications out of the reach of children, never share your medicine with others, and use each medication only as prescribed. Your reliance on any information provided on this platform is at your own risk.

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