KISQALI FEMARA ratings & reviews

Letrozole;Ribociclib
Company: Novartis
Brand: KISQALI FEMARA
Drug class: Antineoplastic and Immunomodulating Agents
+5 more
Antineoplastic and Immunomodulating Agents, Cytostatic Hormone Therapy, Antineoplastics, Small Molecule Antineoplastic Cyclin-Dependent Kinase (CDK) Inhibitors, Cytostatic Hormone Antagonists, Cytostatic Aromatase Inhibitors
Overall rating
3.7
full star full star full star half star empty star
Ranked #13
Physician ratings
  • Efficacy: effective for its intended use
  • Safety: safe to use in humans
  • Tolerability: low drug side effects
  • Accessibility: insurance/payer coverage, cost, affordability,formulary coverage, availability in your hospital or practice setting
  • Adherence: patient compliance with treatment
Efficacy
3.9/5
Safety
3.7/5
Tolerability
3.6/5
Accessibility
3.6/5
Adherence
3.6/5

Sermo AI Overview

  • KISQALI FEMARA is widely regarded as effective in treating hormone receptor-positive breast cancer, earning high efficacy ratings from numerous specialists across various regions, indicating strong confidence in its use.
  • The overall safety and tolerability of KISQALI FEMARA are positively noted by specialists, with many indicating it is well-tolerated and associated with minimal side effects.
  • There are concerns regarding the accessibility and funding of KISQALI FEMARA, with reports suggesting that its availability may differ significantly depending on the region, potentially limiting patient access.
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Based on insights from Sermo’s triple verified physicians

Description

The brand name 'Kisqali Femara' consists of ribociclib in 200 mg film-coated tablets and letrozole in 2.5 mg tablets. Ribociclib, a kinase inhibitor, is available as a free base form, while letrozole is a nonsteroidal aromatase inhibitor. The tablets are intended for oral administration, with ribociclib containing inactive ingredients like colloidal silicon dioxide and magnesium stearate, and letrozole containing lactose monohydrate and titanium dioxide.

Source: This information is sourced from FDA and powered by AI

Dosage & Administration

How should I use this medication?

Take this medication by mouth with a glass of water. Take it as directed on the prescription label at the same time every day. Do not cut, crush, or chew this medication. Swallow the tablets whole. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.

Do not take this medication with grapefruit juice.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose or vomit after taking a dose, do not take another dose on that day. Take your next dose at your regular time.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store between 20 and 25 degrees C (68 and 77 degrees F). Keep this medication in the original package. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, ask your pharmacist or care team how to get rid of this medication safely.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Side Effects

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Dry cough, shortness of breath or trouble breathing
  • Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Rash, fever, and swollen lymph nodes
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Back pain
  • Constipation
  • Diarrhea
  • Fatigue
  • Hair loss
  • Headache
  • Nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings & Precautions

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Heart disease
  • History of irregular heartbeat
  • Infection, such as chickenpox, cold sores, herpes
  • Liver disease
  • Low blood counts, such as low white cells, platelets, red cell counts
  • Low levels of calcium, magnesium, potassium, or phosphorus in the blood
  • Lung or breathing disease, such as asthma
  • Weak bones
  • An unusual or allergic reaction to ribociclib, letrozole, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breastfeeding

What may interact with this medication?

Do not take this medication with any of the following:

  • Alfuzosin
  • Certain antivirals for HIV or hepatitis, such as atazanavir, cobicistat, darunavir, delavirdine, nelfinavir, saquinavir, tipranavir
  • Certain medications for cholesterol, such as lovastatin, simvastatin
  • Certain medications for fungal infections, such as fluconazole, isavuconazonium, posaconazole
  • Conivaptan
  • Cisapride
  • Dronedarone
  • Eletriptan
  • Eplerenone
  • Ergot alkaloids, such as dihydroergotamine or ergotamine
  • Flibanserin
  • Fosamprenavir
  • Ivabradine
  • Lomitapide
  • Lurasidone
  • Naloxegol
  • Pimozide
  • Ranolazine
  • Silodosin
  • Thioridazine
  • Tolvaptan
  • Triazolam
  • Ubrogepant

This medication may interact with the following:

  • Alfentanil
  • Antiviral medications for HIV or AIDS
  • Certain medications for fungal infections, such as ketoconazole, itraconazole, voriconazole
  • Certain medications for seizures, such as carbamazepine, phenobarbital, phenytoin
  • Clarithromycin
  • Cyclosporine
  • Everolimus
  • Fentanyl
  • Grapefruit juice
  • Midazolam
  • Nefazodone
  • Other medications that cause heart rhythm changes, such as dofetilide, ziprasidone
  • Pomegranate juice
  • Quinidine
  • Rifampin
  • Sirolimus
  • St. John's wort
  • Tacrolimus

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication. You may need blood work while taking this medication.

Do not take this medication close to bedtime. It may prevent you from sleeping.

This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.

Avoid taking medications that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your care team. These medications may hide a fever.

Be careful brushing or flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your care team you are receiving this medication.

This medication may increase your risk to bruise or bleed. Call your care team if you notice any unusual bleeding.

Talk to your care team if you may be pregnant. Serious birth defects can occur if you take this medication during pregnancy and for 3 weeks after the last dose. Your will need a negative pregnancy test before starting this medication. Contraception is recommended while taking this medication and for 3 weeks after the last dose. Your care team can help you find the option that works for you.

Do not breastfeed while taking this medication and for 3 weeks after the last dose.

This medication may cause infertility. Talk to your care team if you are concerned about your fertility.

Source: This information is sourced from Elsevier Inc.

Disclaimer

The reviews, ratings, comments, and opinions expressed on this platform are solely those of the individual medical professionals who posted them and do not reflect the views or positions of Sermo, Inc. Sermo does not endorse, verify, or validate the content of individual reviews. The information provided is user-generated and reflects personal clinical experiences, which may not be complete, accurate, or applicable to your specific health needs. It is not intended as medical advice.

Prescription medications affect individuals differently, and what works for one person may not work for another. Always consult your doctor, pharmacist, or other qualified healthcare provider to ensure the information displayed applies to your personal circumstances. Only a licensed healthcare provider can advise you on what is safe and effective for you.

Keep all medications out of the reach of children, never share your medicine with others, and use each medication only as prescribed. Your reliance on any information provided on this platform is at your own risk.

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