What should I tell my care team before I take this medication?
They need to know if you have any of these conditions:
- Heart disease
- History of irregular heartbeat
- Infection, such as chickenpox, cold sores, herpes
- Liver disease
- Low blood counts, such as low white cells, platelets, red cell counts
- Low levels of calcium, magnesium, potassium, or phosphorus in the blood
- Lung or breathing disease, such as asthma
- Weak bones
- An unusual or allergic reaction to ribociclib, letrozole, other medications, foods, dyes, or preservatives
- Pregnant or trying to get pregnant
- Breastfeeding
What may interact with this medication?
Do not take this medication with any of the following:
- Alfuzosin
- Certain antivirals for HIV or hepatitis, such as atazanavir, cobicistat, darunavir, delavirdine, nelfinavir, saquinavir, tipranavir
- Certain medications for cholesterol, such as lovastatin, simvastatin
- Certain medications for fungal infections, such as fluconazole, isavuconazonium, posaconazole
- Conivaptan
- Cisapride
- Dronedarone
- Eletriptan
- Eplerenone
- Ergot alkaloids, such as dihydroergotamine or ergotamine
- Flibanserin
- Fosamprenavir
- Ivabradine
- Lomitapide
- Lurasidone
- Naloxegol
- Pimozide
- Ranolazine
- Silodosin
- Thioridazine
- Tolvaptan
- Triazolam
- Ubrogepant
This medication may interact with the following:
- Alfentanil
- Antiviral medications for HIV or AIDS
- Certain medications for fungal infections, such as ketoconazole, itraconazole, voriconazole
- Certain medications for seizures, such as carbamazepine, phenobarbital, phenytoin
- Clarithromycin
- Cyclosporine
- Everolimus
- Fentanyl
- Grapefruit juice
- Midazolam
- Nefazodone
- Other medications that cause heart rhythm changes, such as dofetilide, ziprasidone
- Pomegranate juice
- Quinidine
- Rifampin
- Sirolimus
- St. John's wort
- Tacrolimus
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medication?
Your condition will be monitored carefully while you are receiving this medication. You may need blood work while taking this medication.
Do not take this medication close to bedtime. It may prevent you from sleeping.
This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
Avoid taking medications that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your care team. These medications may hide a fever.
Be careful brushing or flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your care team you are receiving this medication.
This medication may increase your risk to bruise or bleed. Call your care team if you notice any unusual bleeding.
Talk to your care team if you may be pregnant. Serious birth defects can occur if you take this medication during pregnancy and for 3 weeks after the last dose. Your will need a negative pregnancy test before starting this medication. Contraception is recommended while taking this medication and for 3 weeks after the last dose. Your care team can help you find the option that works for you.
Do not breastfeed while taking this medication and for 3 weeks after the last dose.
This medication may cause infertility. Talk to your care team if you are concerned about your fertility.