Pegasys ratings & reviews

Pegasys contains the active ingredient peginterferon alfa-2a, which is a conjugate of recombinant alfa-2a interferon with a polyethylene glycol chain. It is provided as a sterile injection with a dosage strength of 180 mcg/mL or 180 mcg/0.5 mL intended for subcutaneous administration. Key inactive ingredients include acetic acid, benzyl alcohol, polysorbate 80, sodium acetate trihydrate, and sodium chloride.

How should I use this medication?

This medication is injected under the skin. Do NOT shake this medication. You will be taught how to prepare and give it. Take it as directed on the prescription label at the same time every day. Keep taking it unless your care team tells you to stop.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or care team to get one.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. While this medication may be prescribed for children as young as 3 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose and you remember within 2 days of when you missed your dose, take it as soon as you can. If it is late in the day, wait until the next day to take your dose. If more than 2 days have passed since you missed your dose ask your care team what to do. Do not take double or extra doses.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store in the refrigerator. Do not freeze. Protect from light. Do not leave this medication out of the refrigerator for more than 24 hours. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

• Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, ask your pharmacist or care team how to get rid of this medication safely.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Dry cough, shortness of breath or trouble breathing
• Eye pain, change in vision, vision loss
• Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
• Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
• High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
• High thyroid levels (hyperthyroidism)—fast or irregular heartbeat, weight loss, excessive sweating or sensitivity to heat, tremors or shaking, anxiety, nervousness, irregular menstrual cycle or spotting
• Increase in blood pressure
• Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
• Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
• Low blood sugar (hypoglycemia)—tremors or shaking, anxiety, sweating, cold or clammy skin, confusion, dizziness, rapid heartbeat
• Low thyroid levels (hypothyroidism)—unusual weakness or fatigue, increased sensitivity to cold, constipation, hair loss, dry skin, weight gain, feelings of depression
• Lupus-like syndrome—joint pain, swelling, or stiffness, butterfly-shaped rash on the face, rashes that get worse in the sun, fever, unusual weakness or fatigue
• Mood and behavior changes—anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
• Pain, tingling, or numbness in the hands or feet
• Pancreatitis—severe stomach pain that spreads to your back or gets worse after eating or when touched, fever, nausea, vomiting
• Pulmonary hypertension—shortness of breath, chest pain, fast or irregular heartbeat, feeling faint or lightheaded, fatigue, swelling of the ankles or feet
• Redness, blistering, peeling, or loosening of the skin, including inside the mouth
• Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
• Sudden or severe stomach pain, bloody diarrhea, fever, nausea, vomiting
• Unusual bruising or bleeding

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Diarrhea
• Fatigue
• Fever
• Hair loss
• Headache
• Nausea
• Pain, redness, or irritation at injection site

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Alcohol use disorder
• Auto-immune hepatitis
• Blood or bleeding disorders
• Colitis, such as ulcerative colitis or Crohn's disease
• Depression or other mental health conditions
• Diabetes
• Heart disease
• History of cancer
• Kidney disease
• Lupus
• Psoriasis
• Rheumatoid arthritis
• Substance use disorder
• Thyroid problems
• An unusual or allergic reaction to peginterferon, other medications, foods, dyes, or preservatives like benzyl alcohol
• Pregnant or trying to get pregnant
• Breast-feeding

What may interact with this medication?

• Alcohol
• Medications for HIV, such as didanosine, lamivudine, stavudine, zidovudine
• Methadone
• Theophylline

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. You may need blood work while taking this medication.

This medication may cause serious skin reactions. They can happen weeks to months after starting the medication. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. You may also notice a red rash with swelling of the face, lips, or lymph nodes in your neck or under your arms.

This medication can affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medication. Avoid alcoholic drinks.

This medication may increase blood sugar. The risk may be higher in patients who already have diabetes. Ask your care team what you can do to lower your risk of diabetes while taking this medication.

What are the most serious risks of this medication?

This medicine can increase the risk of having a heart attack or stroke.

This medicine can lower your body’s ability to fight infections. You may get more infections while taking this medicine. Any infection you get could become serious and even deadly.

This medicine can cause serious mental health problems. Patients of all ages and their families should watch for changes, especially sudden changes in mood, behaviors, thoughts, or feelings. Some symptoms to watch for are depression, thoughts of suicide, aggressive behavior, wanting to hurt others, hostility, anger, anxiety, irritability, being suspicious or distrustful, or any unusual or extreme changes in behavior or mood. Call your healthcare provider right away for new or worsening mental problems. Call your healthcare provider as needed, especially if you are worried about symptoms.

This medicine can cause immune system disorders or make them worse. Examples are rheumatoid arthritis, lupus, sarcoidosis, thyroid disease, and psoriasis. Tell your healthcare provider if you have any kind of immune disease.

The use of this medicine with ribavirin requires extra caution. Ribavirin can cause severe birth defects or death to an unborn baby. Pregnant females should not take ribavirin. Females who can become pregnant must use effective birth control during combined treatment and for 6 months after the last dose. Call your healthcare provider if you become pregnant, have unprotected sex, or think your birth control has failed. Males must also use extra care. Males taking ribavirin must always use a condom during sex with female partners who are pregnant or who can get pregnant. If a pregnant woman is exposed to your semen during treatment, it could cause birth defects or death to the unborn baby. Condoms must be used during treatment and for 6 months after the last dose. Tell your healthcare provider right away if your partner becomes pregnant or thinks she is pregnant while you are taking ribavirin.